Interstitial cells of cajal direct normal propulsive contractile activity in the mouse small intestine.

@article{DerSilaphet1998InterstitialCO,
  title={Interstitial cells of cajal direct normal propulsive contractile activity in the mouse small intestine.},
  author={T Der-Silaphet and John Malysz and Stefan Hagel and A Larry Arsenault and Jan D. Huizinga},
  journal={Gastroenterology},
  year={1998},
  volume={114 4},
  pages={724-36}
}
BACKGROUND & AIMS Interstitial cells of Cajal (ICC) have been linked to the generation of intestinal pacemaker activity, but their role in in vivo motor dysfunction is unclear. In this study, we investigated the hypothesis that ICC play a role in the generation of distention-induced peristalsis using W/Wv mice that lack ICC associated with Auerbach's plexus. METHODS Radiological observations were made of the movement of contrast fluid through the proximal small intestine. Electrical… CONTINUE READING

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