Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity.

@article{Klein2013InterstitialCO,
  title={Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity.},
  author={Sabine Klein and B. K. H. Seidler and Anna Kettenberger and Andrei Sibaev and Michael Rohn and Robert Feil and Hans-Dieter Allescher and Jean-Marie Vanderwinden and Franz 12 Hofmann and Michael Schemann and Roland Rad and Martin Alexander Storr and Roland M Schmid and G. R. Eugenia Schneider and Dieter Saur},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={1630}
}
The enteric nervous system contains excitatory and inhibitory neurons, which control contraction and relaxation of smooth muscle cells as well as gastrointestinal motor activity. Little is known about the exact cellular mechanisms of neuronal signal transduction to smooth muscle cells in the gut. Here we generate a c-Kit(CreERT2) knock-in allele to target a distinct population of pacemaker cells called interstitial cells of Cajal. By genetic loss-of-function studies, we show that interstitial… CONTINUE READING

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