Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors.

  title={Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors.},
  author={Kanishka Sircar and Bryan Hewlett and Jan D. Huizinga and Katherine A Chorneyko and Irene Berezin and Robert H. Riddell},
  journal={The American journal of surgical pathology},
  volume={23 4},
Interstitial cells of Cajal (ICC) are implicated in the regulation of gut peristalsis and are immunostained by antibodies against Kit (CD117), a tyrosine kinase receptor. Most gastrointestinal mesenchymal tumors (GIMTs) are of uncertain histogenesis, although many are CD34-positive. CD34 was found to colocalize with vimentin (Vim) and the Kit-positive networks of cells within and around neural plexi, indicating that ICC can be Vim- and CD34-positive. ICCs appear to be the only Kit+CD34+Vim… CONTINUE READING
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