Interstitial and Plasma Adenosine Stimulate Nitric Oxide and Prostacyclin Formation in Human Skeletal Muscle

@article{Nyberg2010InterstitialAP,
  title={Interstitial and Plasma Adenosine Stimulate Nitric Oxide and Prostacyclin Formation in Human Skeletal Muscle},
  author={M. Nyberg and S. Mortensen and P. Thaning and B. Saltin and Y. Hellsten},
  journal={Hypertension},
  year={2010},
  volume={56},
  pages={1102-1108}
}
One major unresolved issue in muscle blood flow regulation is that of the role of circulating versus interstitial vasodilatory compounds. The present study determined adenosine-induced formation of NO and prostacyclin in the human muscle interstitium versus in femoral venous plasma to elucidate the interaction and importance of these vasodilators in the 2 compartments. To this end, we performed experiments on humans using microdialysis technique in skeletal muscle tissue, as well as the femoral… Expand
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