Interstitial Lung Disease Induced by Drugs and Radiation

@article{Camus2004InterstitialLD,
  title={Interstitial Lung Disease Induced by Drugs and Radiation},
  author={Philippe Camus and Annlyse Fanton and Philippe Bonniaud and Clio Camus and Pascal Foucher},
  journal={Respiration},
  year={2004},
  volume={71},
  pages={301 - 326}
}
An ever-increasing number of drugs can reproduce variegated patterns of naturally occurring interstitial lung disease (ILD), including most forms of interstitial pneumonias, alveolar involvement and, rarely, vasculitis. Drugs in one therapeutic class may collectively produce the same pattern of involvement. A few drugs can produce more than one pattern of ILD. The diagnosis of drug-induced ILD (DI-ILD) essentially rests on the temporal association between exposure to the drug and the… 

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References

SHOWING 1-10 OF 123 REFERENCES

Drug-induced pneumonitis: the role of methotrexate.

An exhaustive review of the English literature and identified 189 cases of methotrexate-induced pneumonitis (MIP), with Rheumatoid arthritis was the most frequent underlying disease and the prognosis is usually favorable, but occasionally the outcome may be fatal.

Bronchoalveolar lavage in drug-induced lung disease.

Pulmonary drug toxicity: radiologic and pathologic manifestations.

Pulmonary drug toxicity is increasingly being diagnosed as a cause of acute and chronic lung disease and knowledge of these manifestations and of the drugs most frequently involved can facilitate diagnosis and institution of appropriate treatment.

Infiltrative lung disease due to noncytotoxic agents.

Pathologic characteristics of drug-induced lung disease.

Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients.

It is important that all patients receiving methotrexate be educated concerning this potential adverse reaction and instructed to contact their physicians should significant new pulmonary symptoms develop while undergoing therapy, and if metotrexate pneumonitis is suspected, methotRexate should be discontinued.

Diagnostic Invasive Procedures in Diffuse Infiltrative Lung Diseases

In this article invasive diagnostic procedures in patients with diffuse lung infiltrates are discussed from the perspective of their clinical context and their imaging characteristics.

Methotrexate pulmonary toxicity.

  • G. Cannon
  • Medicine
    Rheumatic diseases clinics of North America
  • 1997

Gold-induced pulmonary disease: clinical features, outcome, and differentiation from rheumatoid lung disease.

  • R. TomiokaT. King
  • Medicine
    American journal of respiratory and critical care medicine
  • 1997
Features that distinguish gold-induced pulmonary disease from rheumatoid lung disease include female predominance, presence of fever or skin rash, absence of subcutaneous nodules or finger clubbing, lymphocytosis in bronchoalveolar lavage fluid (BALF), and alveolar opacities along the bronchovascular bundles on chest CT scan.
...