Interstitial Concentrations of Amino Acids in the Rat Striatum During Global Forebrain Ischemia and Potassium-Evoked Spreading Depression

@article{Molchanova2004InterstitialCO,
  title={Interstitial Concentrations of Amino Acids in the Rat Striatum During Global Forebrain Ischemia and Potassium-Evoked Spreading Depression},
  author={Svetlana M Molchanova and Peeter K{\"o}{\"o}bi and S. S. Oja and Pirjo Saransaari},
  journal={Neurochemical Research},
  year={2004},
  volume={29},
  pages={1519-1527}
}
The early detection and appropriate treatment of brain ischemia is of paramount importance. The interstitial concentrations of neurotransmitter amino acids are often used as an index of neuronal injury. However, monitoring of non-neurotransmitter amino acids may be equally important. We have studied the behavior of 10 amino acids during K+-induced spreading depression (application of 70 mM KCl during 40 min) and global forebrain ischemia (two-vessel occlusion with hypotension during 20 min… CONTINUE READING