Interstitial Ca2+ undergoes dynamic changes sufficient to stimulate nerve-dependent Ca2+-induced relaxation.

We recently described a perivascular sensory nerve-linked dilator system that can be activated by interstitial Ca2+([Formula: see text]). The present study tested the hypothesis that [Formula: see text] in the rat duodenal submucosa varies through a range that is sufficient to activate this pathway. An in situ microdialysis method was used to estimate… CONTINUE READING