Interspecific scaling of toxicity data.

  title={Interspecific scaling of toxicity data.},
  author={C. C. Travis and Richard K. White},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  volume={8 1},
This paper reexamines the scaling approaches used in cancer risk assessment and proposes a more precise body weight scaling factor. Two approaches are conventionally used in scaling exposure and dose from experimental animals to man: body weight scaling (used by FDA) and surface area scaling (BW0.67--used by EPA). This paper reanalyzes the Freireich et al. (1966) study of the maximum tolerated dose (MTD) of 14 anticancer agents in mice, rats, dogs, monkeys, and humans, the dataset most commonly… CONTINUE READING