Interspecific Germline Transmission of Cultured Primordial Germ Cells

  title={Interspecific Germline Transmission of Cultured Primordial Germ Cells},
  author={Marie-Cecile van de Lavoir and Ellen J. Collarini and Philip A. Leighton and Jeffrey Fesler and Daniel R. Lu and William D. Harriman and T. S. Thiyagasundaram and Robert J. Etches},
  booktitle={PloS one},
In birds, the primordial germ cell (PGC) lineage separates from the soma within 24 h following fertilization. Here we show that the endogenous population of about 200 PGCs from a single chicken embryo can be expanded one million fold in culture. When cultured PGCs are injected into a xenogeneic embryo at an equivalent stage of development, they colonize the testis. At sexual maturity, these donor PGCs undergo spermatogenesis in the xenogeneic host and become functional sperm. Insemination of… CONTINUE READING
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