Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22.

@article{Parsons2005InterspeciesSM,
  title={Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22.},
  author={Claire A. Parsons and Henry J Mroczkowski and F E McGuigan and Omar M. E. Albagha and Stavros C Manolagas and David M. Reid and Stuart H. Ralston and Robert J Shmookler Reis},
  journal={Human molecular genetics},
  year={2005},
  volume={14 21},
  pages={3141-8}
}
Bone mineral density (BMD) is a complex trait with a strong genetic component and an important predictor of osteoporotic fracture risk. Here we report the use of a cross-species strategy to identify genes that regulate BMD, proceeding from quantitative trait mapping in mice to association mapping of the syntenic region in the human genome. We identified a quantitative trait locus (QTL) on the mouse X-chromosome for post-maturity change in spine BMD in a cross of SAMP6 and AKR/J mice and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2008
View 1 Excerpt

Quantitative trait loci for BMD and bone strength in an intercross between domestic and wildtype chickens.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2007
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Site and gender specificity of inheritance of bone mineral density.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2003
View 1 Excerpt

Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2001

Similar Papers

Loading similar papers…