Interspecies scaling: prediction of human biliary clearance and comparison with QSPKR.

@article{Morris2012InterspeciesSP,
  title={Interspecies scaling: prediction of human biliary clearance and comparison with QSPKR.},
  author={Marilyn E Morris and Xinning Yang and Yash A. Gandhi and Suraj G. Bhansali and Lisa Jo Benincosa},
  journal={Biopharmaceutics & drug disposition},
  year={2012},
  volume={33 1},
  pages={
          1-14
        }
}
The aim of this study was to evaluate the prediction performance of various allometric scaling methods in predicting human biliary clearance (CL(b)) from data in rats or multiple animal species and to compare the prediction performance with that of quantitative structure pharmacokinetic relationship (QSPKR) models. CL(b) data of parent drugs in rats and humans were collected from the literature for 18 compounds. A simple allometric approach was applied to CL(b) or unbound CL(b) using 0.75 or 0… CONTINUE READING
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