Interspecies nuclear transfer reveals that demethylation of specific repetitive sequences is determined by recipient ooplasm but not by donor intrinsic property in cloned embryos.

@article{Chen2006InterspeciesNT,
  title={Interspecies nuclear transfer reveals that demethylation of specific repetitive sequences is determined by recipient ooplasm but not by donor intrinsic property in cloned embryos.},
  author={Tao Chen and Yanling Zhang and Yan Jiang and Jing-He Liu and Heide Schatten and Da-Yuan Chen and Qing-Yuan Sun},
  journal={Molecular reproduction and development},
  year={2006},
  volume={73 3},
  pages={
          313-7
        }
}
DNA methylation/demethylation of donor genomes in recipient ooplasm after nuclear transfer occurs in a species-specific way. In cloned rabbit and bovine embryos, repetitive sequences maintain the donor-type methylation status, but typical demethylation of repetitive sequences takes place in cloned porcine embryos. To clarify whether the demethylation is controlled by donor nucleus intrinsic property or by recipient ooplasm, we used interspecies somatic cell nuclear transfer (iSCNT) model to… CONTINUE READING
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