Interspecies differences in metabolism of arsenic by cultured primary hepatocytes.

@article{Drobn2010InterspeciesDI,
  title={Interspecies differences in metabolism of arsenic by cultured primary hepatocytes.},
  author={Zuzana Drobn{\^a} and Felecia S. Walton and Anne W. Harmon and David J Thomas and Miroslav Stỳblo},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={245 1},
  pages={47-56}
}
Biomethylation is the major pathway for the metabolism of inorganic arsenic (iAs) in many mammalian species, including the human. However, significant interspecies differences have been reported in the rate of in vivo metabolism of iAs and in yields of iAs metabolites found in urine. Liver is considered the primary site for the methylation of iAs and arsenic (+3 oxidation state) methyltransferase (As3mt) is the key enzyme in this pathway. Thus, the As3mt-catalyzed methylation of iAs in the… CONTINUE READING

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