Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes.

@article{Jemnitz2008InterspeciesDI,
  title={Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes.},
  author={Katalin Jemnitz and Zsuzsa Veres and Katalin Monostory and L{\'a}szl{\'o} K{\'o}bori and L{\'a}szl{\'o} Vereczkey},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2008},
  volume={22 4},
  pages={961-7}
}
Most of the experiments studying acetaminophen (APAP) induced hepatotoxicity were performed using moue as model specie, right because its high sensitivity. While the toxic responses can be called forth easily in mice, the human relevancy of these results is questionable. In this study human, rat, and mouse primary hepatocytes were treated with increasing concentrations of APAP, and cell viability was measured by MTT cytotoxicity assay. Pronounced interspecies differences were obtained in cell… CONTINUE READING

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