Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets.

@article{Greenblatt2012InterspeciesCO,
  title={Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets.},
  author={Matthew Blake Greenblatt and Jennifer L. Sargent and Giuseppina Farina and Kelly Tsang and Robert Lafyatis and L. H. Glimcher and Michael L. Whitfield and Antonios O Aliprantis},
  journal={The American journal of pathology},
  year={2012},
  volume={180 3},
  pages={1080-94}
}
Development of personalized treatment regimens is hampered by lack of insight into how individual animal models reflect subsets of human disease, and autoimmune and inflammatory conditions have proven resistant to such efforts. Scleroderma is a lethal autoimmune disease characterized by fibrosis, with no effective therapy. Comparative gene expression profiling showed that murine sclerodermatous graft-versus-host disease (sclGVHD) approximates an inflammatory subset of scleroderma estimated at… CONTINUE READING
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