Intersex mice composed of androgen insensitive Tfm and wild-type cells analysed by 3H dihydrotestosterone autoradiography

@article{Schleicher2004IntersexMC,
  title={Intersex mice composed of androgen insensitive Tfm and wild-type cells analysed by 3H dihydrotestosterone autoradiography},
  author={G. Schleicher and W. Stumpf and K. Thiedemann and U. Drews},
  journal={Anatomy and Embryology},
  year={2004},
  volume={178},
  pages={521-528}
}
SummaryThe X-linked testicular feminization mutation (Tfm) in the mouse is characterized by an androgen receptor defect. Due to random X-chromosome inactivation, XTfm/X+ heterozygotes are mosaics with respect to Tfm. They are composed of androgen receptor deficient XTfm cells and normal X+ wild-type cells. If Tfm heterozygotes are converted to XX males by the sex reversal factor (Sxr) the mosaicism is expressed. Therefore in sex reversed Tfm heterozygotes (XTfm/X+-Sxr) intersexual sex organs… Expand
2 Citations
Helper Function of the Wolffian Ducts and Role of Androgens in the Development of the Vagina
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  • Sexual Development
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References

SHOWING 1-10 OF 32 REFERENCES
X-inactivation pattern in the epididymis of sex-reversed mice heterozygous for testicular feminization.
  • 20
Cytosol androgen receptor from kidney of normal and testicular feminized (Tfm) mice.
  • 120
Stimulation of growth by testosterone via the mesenchyme
  • 4
...
1
2
3
4
...