Intersecting transcription networks constrain gene regulatory evolution

@inproceedings{Sorrells2015IntersectingTN,
  title={Intersecting transcription networks constrain gene regulatory evolution},
  author={Trevor R Sorrells and Lauren N. Booth and Brian B. Tuch and Alexander Johnson},
  booktitle={Nature},
  year={2015}
}
Epistasis—the non-additive interactions between different genetic loci—constrains evolutionary pathways, blocking some and permitting others. For biological networks such as transcription circuits, the nature of these constraints and their consequences are largely unknown. Here we describe the evolutionary pathways of a transcription network that controls the response to mating pheromone in yeast. A component of this network, the transcription regulator Ste12, has evolved two different modes of… CONTINUE READING
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