Interruption of the enterohepatic circulation of digitoxin by cholestyramine. I. Protection against lethal digitoxin intoxication.

@article{Caldwell1971InterruptionOT,
  title={Interruption of the enterohepatic circulation of digitoxin by cholestyramine. I. Protection against lethal digitoxin intoxication.},
  author={James H. Caldwell and Norton J. Greenberger},
  journal={The Journal of clinical investigation},
  year={1971},
  volume={50 12},
  pages={2626-37}
}
Previous studies have demonstrated that considerable amounts of parenterally administered cardiac glycosides are excreted in the bile and reabsorbed across the intestinal mucosa in several species. It is currently believed that the more prolonged action of nonpolar digitalis glycosides is due to their retention and recycling in the enterohepatic circulation… CONTINUE READING