Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival.

@article{Yeung2013InterruptionOD,
  title={Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival.},
  author={Melissa Y. Yeung and Martina M. McGrath and Masafumi Nakayama and Tetsunosuke Shimizu and Olaf Boenisch and Ciara N. Magee and Rozita Abdoli and Hisaya Akiba and Takuya Ueno and Laurence A Turka and Nader Najafian},
  journal={Journal of immunology},
  year={2013},
  volume={191 8},
  pages={4447-55}
}
Dendritic cells (DCs) are the central architects of the immune response, inducing inflammatory or tolerogenic immunity, dependent on their activation status. As such, DCs are highly attractive therapeutic targets and may hold the potential to control detrimental immune responses. TIM-4, expressed on APCs, has complex functions in vivo, acting both as a costimulatory molecule and a phosphatidylserine receptor. The effect of TIM-4 costimulation on T cell activation remains unclear. In this study… CONTINUE READING
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