Interruption of a basal ganglia–forebrain circuit prevents plasticity of learned vocalizations

@article{Brainard2000InterruptionOA,
  title={Interruption of a basal ganglia–forebrain circuit prevents plasticity of learned vocalizations},
  author={M. Brainard and A. Doupe},
  journal={Nature},
  year={2000},
  volume={404},
  pages={762-766}
}
Birdsong, like speech, is a learned vocal behaviour that relies greatly on hearing; in both songbirds and humans the removal of auditory feedback by deafening leads to a gradual deterioration of adult vocal production. Here we investigate the neural mechanisms that contribute to the processing of auditory feedback during the maintenance of song in adult zebra finches. We show that the deleterious effects on song production that normally follow deafening can be prevented by a second insult to… Expand
Deafening-Induced Vocal Deterioration in Adult Songbirds Is Reversed by Disrupting a Basal Ganglia-Forebrain Circuit
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In birds, the contribution of basal ganglia-thalamic-cortical circuits to motor control may change when feedback is absent or unexpected and includes both “active” and “permissive” roles. Expand
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  • Psychology, Medicine
  • Annals of the New York Academy of Sciences
  • 2004
Abstract: A hallmark of sensitive periods of development is an enhanced capacity for learning, such that experience exerts a profound effect on the brain resulting in the establishment of behaviorsExpand
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TLDR
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Birdsong is a learned, sequenced motor skill. For the zebra finch, learned song normally remains unchanging beyond early adulthood. However, stable adult song will gradually deteriorate afterExpand
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  • M. Brainard
  • Psychology, Medicine
  • Annals of the New York Academy of Sciences
  • 2004
TLDR
This chapter reviews some of the experimental evidence supporting a role for the anterior forebrain pathway in song learning and vocal plasticity and discusses potential instructive and permissive functions of the AFP in vocal Plasticity. Expand
Auditory-Dependent Vocal Recovery in Adult Male Zebra Finches Is Facilitated by Lesion of a Forebrain Pathway That Includes the Basal Ganglia
TLDR
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Intrinsic and Extrinsic Contributions to Auditory Selectivity in a Song Nucleus Critical for Vocal Plasticity
TLDR
In vivo intracellular recordings from LMAN projection neurons, coupled with local circuit inactivation, reveal that much of LMAN′s song selectivity is supplied by its extrinsic inputs, but selective blockade of GABA receptors indicates that local inhibition is required for the expression ofsong selectivity. Expand
Song selectivity and sensorimotor signals in vocal learning and production.
TLDR
Experiments that explore a role for the songbird anterior forebrain pathway (AFP), a basal ganglia-forebrain circuit, in evaluating song feedback and modifying vocal output illustrate that sensory and motor processes are highly interrelated in this circuit devoted to vocal learning, as is true for brain areas involved in speech. Expand
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References

SHOWING 1-10 OF 43 REFERENCES
Identification of a forebrain motor programming network for the learned song of zebra finches
  • E. Vu, M. Mazurek, Y. Kuo
  • Psychology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
TLDR
The study of the motor control system for birdsong has provided the most direct evidence to date for localizing the programming of a skilled motor sequence to the telencephalon and the observation that unilateral forebrain perturbation was sufficient to alter the pattern of this bilaterally organized behavior suggests that (non-auditory) feedback pathways to the forebrain exist to coordinate the two hemispheres during singing. Expand
Song- and Order-Selective Neurons in the Songbird Anterior Forebrain and their Emergence during Vocal Development
  • A. Doupe
  • Psychology, Medicine
  • The Journal of Neuroscience
  • 1997
TLDR
The auditory response properties of neurons in the anterior forebrain (AF) pathway of the songbird brain were investigated and provided one of the clearest examples of experience-dependent acquisition of complex stimulus selectivity. Expand
Decrystallization of adult birdsong by perturbation of auditory feedback
TLDR
Evidence is presented that auditory feedback is actively used in adulthood to maintain the stability of song structure in adult zebra finches, and that adult birds that do not learn new songs nevertheless retain a significant amount of plasticity in the brain. Expand
Long-term maintenance of song in adult zebra finches is not affected by lesions of a forebrain region involved in song learning.
TLDR
While deafening produces alterations in song structure within 16 weeks, bilateral destruction of the IMAN did not produce any substantial changes in song over this same period, suggesting that the pathways through which auditory feedback affects adult song behavior do not involve theIMAN. Expand
Singing-Related Neural Activity in a Dorsal Forebrain–Basal Ganglia Circuit of Adult Zebra Finches
TLDR
The singing-related activity of neurons in AFP nuclei of songbirds is consistent with a role of the AFP in adult singing or song maintenance, possibly related to the function of this circuit during initial song learning. Expand
A comparative study of the behavioral deficits following lesions of various parts of the zebra finch song system: implications for vocal learning
  • C. Scharff, F. Nottebohm
  • Psychology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1991
TLDR
It is concluded that Area X and LMAN contribute differently to song acquisition: the song variability that is typical of vocal development persists following early deafness or lesions of Area X but ends abruptly following removal of LMAN. Expand
Selective impairment of song learning following lesions of a forebrain nucleus in the juvenile zebra finch.
TLDR
It is reported here that lesioning Area X disrupts normal song development in juvenile birds, but does not affect the production of stereotyped song by adult birds, and the behavioral results suggest Area X is important for either the acquisition of a song model or the improvement of song through vocal practice. Expand
Auditory feedback is necessary for the maintenance of stereotyped song in adult zebra finches.
TLDR
It is reported here that in the Australian zebra finch, stereotyped song patterns gradually change in adult males following bilateral cochlear removal, indicating that continued auditory input is necessary to maintain the patterns of neural organization supporting learned song in zebra Finches and raising questions concerning the neural sites and cellular mechanisms that mediate this feedback control. Expand
Birdsong and human speech: common themes and mechanisms.
TLDR
Human speech and birdsong have numerous parallels, with striking similarities in how sensory experience is internalized and used to shape vocal outputs, and how learning is enhanced during a critical period of development. Expand
Changes in adult zebra finch song require a forebrain nucleus that is not necessary for song production.
TLDR
Song plasticity induced in adult zebra finches with crystallized songs requires the presence of LMAN, a nucleus which had been thought to play a role in vocal production only during song learning. Expand
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