Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease.

Abstract

BACKGROUND Allergic asthma is a T(H)2-promoted hyperreactivity with an immediate, IgE, and mast cell-dependent response followed by eosinophil-dominated inflammation and airway obstruction. OBJECTIVE Because costimulation by CD28 is essential for T(H)2 but not T(H)1 responses, we investigated the effect of selective interference with this pathway in mice… (More)
DOI: 10.1016/j.jaci.2012.08.049

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