Interrupting the Nazarov cyclization with indoles.

@article{Basak2008InterruptingTN,
  title={Interrupting the Nazarov cyclization with indoles.},
  author={Ashok K Basak and Marcus A Tius},
  journal={Organic letters},
  year={2008},
  volume={10 18},
  pages={4073-6}
}
A carbon-terminated interrupted Nazarov reaction is described. The trimethylsilyl enol ethers derived from propargyl vinyl ketones undergo selective proton transfer at the distal acetylenic carbon atom to provide allenyl vinyl ketones as transient intermediates. In the presence of indoles, a cascade of reactions is initiated that converts the initially… CONTINUE READING