Interrogation of a context-specific transcription factor network identifies novel regulators of pluripotency.

@article{Kushwaha2015InterrogationOA,
  title={Interrogation of a context-specific transcription factor network identifies novel regulators of pluripotency.},
  author={Ritu Kushwaha and Nirmala Jagadish and Manjunath Kustagi and Mark J. Tomishima and Geetu Mendiratta and Mukesh Bansal and Hyunjae R Kim and Pavel Sumazin and Mariano J. Alvarez and C{\'e}line Lefebvre and Patricia Villagrasa-Gonzalez and Agnes Viale and James Korkola and Jane Houldsworth and Darren R Feldman and George J. Bosl and Andrea Califano and Raju S. K. Chaganti},
  journal={Stem cells},
  year={2015},
  volume={33 2},
  pages={367-77}
}
The predominant view of pluripotency regulation proposes a stable ground state with coordinated expression of key transcription factors (TFs) that prohibit differentiation. Another perspective suggests a more complexly regulated state involving competition between multiple lineage-specifying TFs that define pluripotency. These contrasting views were developed from extensive analyses of TFs in pluripotent cells in vitro. An experimentally validated, genome-wide repertoire of the regulatory… CONTINUE READING
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