Interrogating the Escherichia coli cell cycle by cell dimension perturbations

@article{Zheng2016InterrogatingTE,
  title={Interrogating the Escherichia coli cell cycle by cell dimension perturbations},
  author={Hai Zheng and Po-yi Ho and Meiling Jiang and B. G. Tang and Weirong Liu and Dengjin Li and Xuefeng Yu and Nancy Kleckner and Ariel Amir and Chenli Liu},
  journal={Proceedings of the National Academy of Sciences},
  year={2016},
  volume={113},
  pages={15000 - 15005}
}
Significance How bacteria regulate cell division to achieve cell size homeostasis, with concomitant coordination of DNA replication, is a fundamental question. Currently, there exist several competing models for cell cycle regulation in Escherichia coli. We performed experiments where we systematically perturbed cell dimensions and found that average cell volume scales exponentially with the product of the growth rate and the time from initiation of DNA replication to the corresponding cell… 

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