Interrogating local population structure for fine mapping in genome-wide association studies

@article{Qin2010InterrogatingLP,
  title={Interrogating local population structure for fine mapping in genome-wide association studies},
  author={Huaizhen Qin and Nathan Morris and Sun J. Kang and Mingyao Li and Bamidele Tayo and Helen Lyon and Joel Hirschhorn and Richard S. Cooper and Xiaofeng Zhu},
  journal={Bioinformatics},
  year={2010},
  volume={26 23},
  pages={2961-8}
}
MOTIVATION Adjustment for population structure is necessary to avoid bias in genetic association studies of susceptibility variants for complex diseases. Population structure may differ from one genomic region to another due to the variability of individual ancestry associated with migration, random genetic drift or natural selection. Current association methods for correcting population stratification usually involve adjustment of global ancestry between study subjects. RESULTS We suggest… CONTINUE READING

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