Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5'-iodothyronine deiodinase in rat brown adipose tissue.

@article{Silva1986InterrelationshipsAT,
  title={Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5'-iodothyronine deiodinase in rat brown adipose tissue.},
  author={J Enrique Silva and P. R. Larsen},
  journal={The Journal of clinical investigation},
  year={1986},
  volume={77 4},
  pages={1214-23}
}
Thyroxine (T4) and reverse triiodothyronine are potent inhibitors of brown adipose T4 5'-deiodinase (BAT 5'D). This effect does not require protein synthesis and is due to an acceleration of the rate of disappearance of the enzyme. Growth hormone (GH) also inhibits BAT 5'D but by a mechanism mediated through a long-lived messenger that correlates with growth rate. This explains the failure of BAT 5'D to increase abruptly after thyroidectomy as does the type II 5'-deiodinase in pituitary and… CONTINUE READING
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Qualitative and quantitative differences in the pathways of extrathyroidal T 3 generation between euthyroid and hypothyroid rats

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  • 1984

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