Interrelationships among cortisol, 17-hydroxyprogesterone, and androstenendione exposures in the management of children with congenital adrenal hyperplasia.

@article{Sarafoglou2015InterrelationshipsAC,
  title={Interrelationships among cortisol, 17-hydroxyprogesterone, and androstenendione exposures in the management of children with congenital adrenal hyperplasia.},
  author={Kyriakie Sarafoglou and Cheryl L. Zimmerman and Maria Teresa Gonzalez-Bolanos and Brian A Willis and Richard Brundage},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year={2015},
  volume={63 1},
  pages={35-41}
}
UNLABELLED Hydrocortisone is the standard replacement therapy for children with congenital adrenal hyperplasia (CAH). Relationships between cortisol exposures and pharmacodynamic responses of 17-hydroxyprogesterone and androstenedione exposures have not been systematically evaluated. OBJECTIVES (1) Assess individual oral hydrocortisone pharmacokinetics; (2) relate the observed cortisol exposure in each subject to the observed exposures of 17-hydroxyprogesterone and androstenedione; (3… CONTINUE READING