Interrelationships Between Structure and the Properties of Amorphous Solids of Pharmaceutical Interest.

@article{Zografi2017InterrelationshipsBS,
  title={Interrelationships Between Structure and the Properties of Amorphous Solids of Pharmaceutical Interest.},
  author={George D Zografi and Ann E. Newman},
  journal={Journal of pharmaceutical sciences},
  year={2017},
  volume={106 1},
  pages={
          5-27
        }
}
This commentary explores fundamental issues associated with the structure of amorphous solids of pharmaceutical interest in terms of the effects of such structure on: various thermodynamic properties; the glass transition temperature, Tg, physical aging of glasses, polyamorphism; molecular mobility by primary diffusive and secondary Johari-Goldstein relaxations; solid-state crystallization; water vapor absorption; and the formation of active pharmaceutical ingredients-polymer dispersions… CONTINUE READING
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