Interrelation between activation and polymerization in gramicidin S biosynthesis.

@article{Kleinkauf1969InterrelationBA,
  title={Interrelation between activation and polymerization in gramicidin S biosynthesis.},
  author={Horst Kleinkauf and Wieland Gevers and Fritz Lipmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1969},
  volume={62 1},
  pages={226-33}
}
The nucleic acid-independent biosynthesis of the peptide antibiotic gramicidin S results from the interaction of an enzyme bearing phenylalanine in activated form with a polyenzyme system charged with the other four component amino acids. After reaction with ATP, magnesium, and any or all of its amino acid substrates, the polyenzyme system (mol wt 280,000… CONTINUE READING