Corpus ID: 138340141

Interrelation between Disintegration, Dissolution and Permeation of Orodispersible Films (ODFs) Containing Ketoprofen

@inproceedings{Krampe2014InterrelationBD,
  title={Interrelation between Disintegration, Dissolution and Permeation of Orodispersible Films (ODFs) Containing Ketoprofen},
  author={R. Krampe and Daniel Sieber and M. Sascha and E. Haltner-Ukomadu and Miriam Pein and P. Kleinebudde and J. Breitkreutz},
  year={2014}
}
  • R. Krampe, Daniel Sieber, +4 authors J. Breitkreutz
  • Published 2014
  • Materials Science
  • Sodium hydroxide solution as solvent transferred ketoprofen from the poorly soluble acidic form to the freely soluble sodium salt. Faster disintegration (500 µm: 9.67 s) and dissolution (release after 180 s: 500 µm: 47.45%) were detected compared to films made from organic solvents or suspensions, which fits well to the good solubility of ketoprofen sodium. As expected, the slowest permeation (4.28*10-6cm/s) was detected for ketoprofen films based on sodium hydroxide. In films based on organic… CONTINUE READING