Interpreting raised serum prolactin results

  title={Interpreting raised serum prolactin results},
  author={A Levy},
  journal={BMJ : British Medical Journal},
  • A. Levy
  • Published 23 May 2014
  • Medicine
  • BMJ : British Medical Journal
The author explores how doctors in primary care can identify, investigate, and refer patients with hyperprolactinaemia 
Adjunctive aripiprazole in risperidone-induced hyperprolactinaemia: double-blind, randomised, placebo-controlled trial
Adjunctive aripiprazole reduced prolactin levels in those treated with risperidone, with no effect on psychopathology and extrapyramidal symptoms, and is a potential treatment for hyperprolactinaemia observed during treatment with second-generation antipsychotics. Expand
Bioética y veracidad. Cuando la palabra del médico puede llegar a profundizar el desvalimiento del paciente
The reflections recorded in this article consider the way in which the general practitioner can interpret and apply the rule referring to the patient’s right to know the truth based on theirExpand


Diagnosis and management of hyperprolactinemia: Results of a Brazilian multicenter study with 1234 patients
Although PRL levels could not reliably define the etiology of hyperprolactinemia, PRL values >500 ng/ml were exclusively seen in patients with prolactinomas, and CAB was significantly more effective than BCR in terms of Prolactin normalization, tumor shrinkage, and tolerability. Expand
The prevalence of hyperprolactinaemia in overt and subclinical hypothyroidism.
Investigation of the prevalence of hyperprolactinaemia in patients with newly diagnosed subclinical and overt hypothyroidism and the change in PRL levels with treatment found that PRL regulation is altered in overt and subclinical hypothy thyroid disease, and the levels normalize with appropriate L-thyroxine treatment. Expand
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.
This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence for diagnosis and treatment of hyperprolactinemia. Expand
Antipsychotic-Induced Hyperprolactinemia: A Cross-Sectional Survey
In patients using antipsychotics with Prolactin-elevating potential, prolactin levels should be routinely measured to prevent potential long-term complications of "silent" hyperprolactinemia, although this population is still in the early stages of knowing what to do with the information. Expand
Prolactin secretion in polycystic ovary syndrome (PCO): correlation with the steroid pattern.
Hyperprolactinaemia is as relatively frequent condition which affects almost half the patients suffering from PCO and is probably related to an increase of serum oestrogens, mostly oestrone. Expand
Hyperprolactinemia in patients with renal insufficiency and chronic renal failure requiring hemodialysis or chronic ambulatory peritoneal dialysis.
  • S. Hou, S. Grossman, M. Molitch
  • Medicine
  • American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1985
In patients with chronic renal failure prolactin levels were similar regardless of the method of dialysis, and hyperprolactinemia occurs infrequently and, when it occurs, is mild. Expand
Antipsychotic‐Induced Hyperprolactinemia
To prevent or alleviate the condition, tailoring an antipsychotic drug regimen to each individual patient is essential, and the risk of hyperprolactinemia can be minimized by using the lowest effective dose of the antipsychotics agent. Expand
Prolactin response to metoclopramide and thyrotropin-releasing hormone in normoprolactinemic and hyperprolactinemic women: a comparison of diagnostic validity.
  • S. Bussen, N. Brosemann, T. Steck
  • Medicine
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 1996
The objective was to define the diagnostic validity of prolactin response tests by comparing the stimulating effect of thyrotropin-releasing hormone (TRH) and metoclopramide on prolactin secretion inExpand
Prolactin levels, endothelial dysfunction, and the risk of cardiovascular events and mortality in patients with CKD.
BACKGROUND AND OBJECTIVES Both prolactin clearance and production are altered in CKD. In nonrenal populations, emerging evidence suggests that prolactin participates in the atherosclerotic process.Expand
Prolactin, Psychological Stress and Environment in Humans: Adaptation and Maladaptation
It is proposed that prolactin is a component of a biological, “maternal”, subroutine, adaptive to the care of the young, which promotes accumulation of fat for the extraordinary expenses of pregnancy and lactation, the production of milk and maternal behavior. Expand