Interpreting raised serum prolactin results

@article{Levy2014InterpretingRS,
  title={Interpreting raised serum prolactin results},
  author={A Levy},
  journal={BMJ : British Medical Journal},
  year={2014},
  volume={348}
}
  • A. Levy
  • Published 23 May 2014
  • Medicine
  • BMJ : British Medical Journal
The author explores how doctors in primary care can identify, investigate, and refer patients with hyperprolactinaemia 
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TLDR
Although PRL levels could not reliably define the etiology of hyperprolactinemia, PRL values >500 ng/ml were exclusively seen in patients with prolactinomas, and CAB was significantly more effective than BCR in terms of Prolactin normalization, tumor shrinkage, and tolerability. Expand
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Investigation of the prevalence of hyperprolactinaemia in patients with newly diagnosed subclinical and overt hypothyroidism and the change in PRL levels with treatment found that PRL regulation is altered in overt and subclinical hypothy thyroid disease, and the levels normalize with appropriate L-thyroxine treatment. Expand
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This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence for diagnosis and treatment of hyperprolactinemia. Expand
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TLDR
In patients using antipsychotics with Prolactin-elevating potential, prolactin levels should be routinely measured to prevent potential long-term complications of "silent" hyperprolactinemia, although this population is still in the early stages of knowing what to do with the information. Expand
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Hyperprolactinaemia is as relatively frequent condition which affects almost half the patients suffering from PCO and is probably related to an increase of serum oestrogens, mostly oestrone. Expand
Hyperprolactinemia in patients with renal insufficiency and chronic renal failure requiring hemodialysis or chronic ambulatory peritoneal dialysis.
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In patients with chronic renal failure prolactin levels were similar regardless of the method of dialysis, and hyperprolactinemia occurs infrequently and, when it occurs, is mild. Expand
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TLDR
To prevent or alleviate the condition, tailoring an antipsychotic drug regimen to each individual patient is essential, and the risk of hyperprolactinemia can be minimized by using the lowest effective dose of the antipsychotics agent. Expand
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The objective was to define the diagnostic validity of prolactin response tests by comparing the stimulating effect of thyrotropin-releasing hormone (TRH) and metoclopramide on prolactin secretion inExpand
Prolactin levels, endothelial dysfunction, and the risk of cardiovascular events and mortality in patients with CKD.
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It is proposed that prolactin is a component of a biological, “maternal”, subroutine, adaptive to the care of the young, which promotes accumulation of fat for the extraordinary expenses of pregnancy and lactation, the production of milk and maternal behavior. Expand
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