Interpreting aCGH-defined karyotypic changes in gliomas using copy number status, loss of heterozygosity and allelic ratios.

@article{Cowell2010InterpretingAK,
  title={Interpreting aCGH-defined karyotypic changes in gliomas using copy number status, loss of heterozygosity and allelic ratios.},
  author={John K Cowell and Ken C Lo and Jesse D. Luce and Lesleyann Hawthorn},
  journal={Experimental and molecular pathology},
  year={2010},
  volume={88 1},
  pages={82-9}
}
We have used SNP mapping arrays to simultaneously record copy number changes, loss of heterozygosity and allele ratios (ploidy) in a series of 13 gliomas. This combined analysis has defined novel amplification events in this tumor type involving chr1:241544532-243005121 and chr18:54716681-54917277 which contain the AKT3 and ZNF532 genes, respectively. The… CONTINUE READING