Interpretation of thyroid function tests

@article{Dayan2001InterpretationOT,
  title={Interpretation of thyroid function tests},
  author={Colin M. Dayan},
  journal={The Lancet},
  year={2001},
  volume={357},
  pages={619-624}
}
  • C. Dayan
  • Published 24 February 2001
  • Medicine, Biology
  • The Lancet
View on Elsevier
keck.usc.edu
148 Citations
Highly Influential Citations
10
Background Citations
36
Methods Citations
8
Results Citations
1

148 Citations

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Citation Type

Interpretation of thyroid function tests
Thyroid function tests are one of the most common endocrine panels in general practice because a good understanding of when to order them, interpretation of their results and indications for…
Thyroid function tests and its interpretation
TLDR
In the patients with obvious features of hypothyroidism or hyperthyroidism thyroid function tests only confirm the diagnosis, though TSH is widely used as a screening test in suspicion with thyroid disorder, many times TSH alone may be misleading.
Should Free Thyroxine Go Back into the Routine Thyroid Profile?
TLDR
The cost of identifying pituitary insufficiency by measuring both fT4 and TSH was estimated for the population (in 2004 and 2013) and compared with 2 other relevant studies and has become cheaper with time.
Laboratory tests of thyroid function: pitfalls in interpretation
When the clinical suspicion is strong (e.g. in a patient who exhibits overt symptoms and signs of hyperthyroidism), thyroid function tests are helpful in confirming the diagnosis. However, situations…
Optimization of the thyroid panel for diagnostic purposes: Thyrotropin cut-off values for the reflex addition of free thyroxine.
Thyrotropin isoforms: implications for thyrotropin analysis and clinical practice.
TLDR
This review focuses on the dissociation between the clinical state and serum TSH concentrations and addresses clinically important aspects of TSH analysis.
Interpretation of Thyroid Function Tests and Their Relationship to Iodine Nutrition: Changes in TSH, Free T4, and Free T3 Resulting from Iodine Deficiency and Iodine Excess
Unexpected Elevated Free Thyroid Hormones in Pregnancy
TLDR
A 35-year-old woman with a known diagnosis of chronic autoimmune thyroiditis was referred to the authors' clinic at week 26 of her second pregnancy, and was clinically euthyroid.
UPDATE ON THYROID DISORDERS
The thyroid gland regulates metabolism, therefore thyroid dysfunction has an impact throughout the body In iodine-replete areas, autoimmune disease is the commonest cause of thyroid disorders Thyroid…
Management of subclinical hypothyroidism.
TLDR
Patients with symptoms suggestive of hypothyroidism and those patients with thyroid-stimulating hormone (TSH) levels higher than 10 μIU per mL (10 mIU per L) or positive anti-thyroid peroxidase (TPO) antibodies are treated with levothyroxine.
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References

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American Thyroid Association assessment of current free thyroid hormone and thyrotropin measurements and guidelines for future clinical assays. The Committee on Nomenclature of the American Thyroid Association.
The following Special Report from the Committee on Nomenclature of the American Thyroid Association (A TA) is an attempt to clarify some of the confusion that exists on the use and performance of the…
FINE ADJUSTMENT OF THYROXINE REPLACEMENT DOSAGE: COMPARISON OF THE THYROTROPHIN RELEASING HORMONE TEST USING A SENSITIVE THYROTROPHIN ASSAY WITH MEASUREMENT OF FREE THYROID HORMONES AND CLINICAL ASSESSMENT
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Clinical observations, FT3 and FT4 assays were relatively insensitive to small alterations of thyroxine dosage, in contrast to which basal TSH measurements correlated well with TRH responsiveness and were sensitive to fine adjustments of thyoxine dosage.
Thyroid function testing in psychiatric illness: Usefulness and limitations
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If manufacturers and laboratories collaborate to solve the sensitivity and specificity problems discussed here, clinical laboratories should be better able to consistently deliver reliable serum TSH measurements across the full range of TSH concentrations encountered in clinical practice.
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TLDR
This test has no advantage over basal TSH in central hypothyroidism diagnosis and gives many misleading results and have an elevated cost/benefit ratio as compared with the characteristic combination of low thyroxinemia and non elevated TSH0.
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TLDR
The data showed that both serum TSH and Tg concentrations fell over time with single monoexpontential suppression patterns and were proportional to the thyroxine dose administered, which emphasizes the work of Larsen and others showing that it is local T 3' generated from T 4 within the pituitary by the 5'­ deiodinase enzyme system(s), that mediates thyrox­ ine's negative feedback on pituitsary TSH secretion.
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TLDR
In practice, the clinician must differentiate the changes in the serum thyroid hormone lcvels induced by illness from those caused by treatable disorders of thyroid function.
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