Interpretation of thyroid function tests

@article{Dayan2001InterpretationOT,
  title={Interpretation of thyroid function tests},
  author={Colin M. Dayan},
  journal={The Lancet},
  year={2001},
  volume={357},
  pages={619-624}
}
  • C. Dayan
  • Published 24 February 2001
  • Medicine, Biology
  • The Lancet
Interpretation of thyroid function tests
Thyroid function tests are one of the most common endocrine panels in general practice because a good understanding of when to order them, interpretation of their results and indications for
Thyroid function tests and its interpretation
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In the patients with obvious features of hypothyroidism or hyperthyroidism thyroid function tests only confirm the diagnosis, though TSH is widely used as a screening test in suspicion with thyroid disorder, many times TSH alone may be misleading.
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When the clinical suspicion is strong (e.g. in a patient who exhibits overt symptoms and signs of hyperthyroidism), thyroid function tests are helpful in confirming the diagnosis. However, situations
Thyrotropin isoforms: implications for thyrotropin analysis and clinical practice.
TLDR
This review focuses on the dissociation between the clinical state and serum TSH concentrations and addresses clinically important aspects of TSH analysis.
Unexpected Elevated Free Thyroid Hormones in Pregnancy
TLDR
A 35-year-old woman with a known diagnosis of chronic autoimmune thyroiditis was referred to the authors' clinic at week 26 of her second pregnancy, and was clinically euthyroid.
UPDATE ON THYROID DISORDERS
The thyroid gland regulates metabolism, therefore thyroid dysfunction has an impact throughout the body In iodine-replete areas, autoimmune disease is the commonest cause of thyroid disorders Thyroid
Management of subclinical hypothyroidism.
TLDR
Patients with symptoms suggestive of hypothyroidism and those patients with thyroid-stimulating hormone (TSH) levels higher than 10 μIU per mL (10 mIU per L) or positive anti-thyroid peroxidase (TPO) antibodies are treated with levothyroxine.
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References

SHOWING 1-10 OF 60 REFERENCES
American Thyroid Association assessment of current free thyroid hormone and thyrotropin measurements and guidelines for future clinical assays. The Committee on Nomenclature of the American Thyroid Association.
The following Special Report from the Committee on Nomenclature of the American Thyroid Association (A TA) is an attempt to clarify some of the confusion that exists on the use and performance of the
FINE ADJUSTMENT OF THYROXINE REPLACEMENT DOSAGE: COMPARISON OF THE THYROTROPHIN RELEASING HORMONE TEST USING A SENSITIVE THYROTROPHIN ASSAY WITH MEASUREMENT OF FREE THYROID HORMONES AND CLINICAL ASSESSMENT
TLDR
Clinical observations, FT3 and FT4 assays were relatively insensitive to small alterations of thyroxine dosage, in contrast to which basal TSH measurements correlated well with TRH responsiveness and were sensitive to fine adjustments of thyoxine dosage.
Thyroid function testing in psychiatric illness: Usefulness and limitations
  • R. Arem, K. Cusi
  • Medicine, Psychology
    Trends in Endocrinology & Metabolism
  • 1997
Current status and performance goals for serum thyrotropin (TSH) assays.
TLDR
If manufacturers and laboratories collaborate to solve the sensitivity and specificity problems discussed here, clinical laboratories should be better able to consistently deliver reliable serum TSH measurements across the full range of TSH concentrations encountered in clinical practice.
[TSH determination in central hypothyroidism].
  • F. Bakiri
  • Medicine, Biology
    Annales d'endocrinologie
  • 1999
TLDR
This test has no advantage over basal TSH in central hypothyroidism diagnosis and gives many misleading results and have an elevated cost/benefit ratio as compared with the characteristic combination of low thyroxinemia and non elevated TSH0.
Dynamics of thyroid hormone suppression of serum thyrotropin: an invited commentary.
  • C. Spencer
  • Medicine, Biology
    European journal of endocrinology
  • 1996
TLDR
The data showed that both serum TSH and Tg concentrations fell over time with single monoexpontential suppression patterns and were proportional to the thyroxine dose administered, which emphasizes the work of Larsen and others showing that it is local T 3' generated from T 4 within the pituitary by the 5'­ deiodinase enzyme system(s), that mediates thyrox­ ine's negative feedback on pituitsary TSH secretion.
Syndromes of thyrotoxicosis with low radioactive iodine uptake.
  • D. Ross
  • Medicine, Biology
    Endocrinology and metabolism clinics of North America
  • 1998
The sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism
TLDR
In practice, the clinician must differentiate the changes in the serum thyroid hormone lcvels induced by illness from those caused by treatable disorders of thyroid function.
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