Interpretation of thyroid function tests

  title={Interpretation of thyroid function tests},
  author={Colin M. Dayan},
  journal={The Lancet},
  • C. Dayan
  • Published 24 February 2001
  • Medicine, Biology
  • The Lancet
Interpretation of thyroid function tests
Thyroid function tests are one of the most common endocrine panels in general practice because a good understanding of when to order them, interpretation of their results and indications for
Thyroid function tests and its interpretation
In the patients with obvious features of hypothyroidism or hyperthyroidism thyroid function tests only confirm the diagnosis, though TSH is widely used as a screening test in suspicion with thyroid disorder, many times TSH alone may be misleading.
Should Free Thyroxine Go Back into the Routine Thyroid Profile?
The cost of identifying pituitary insufficiency by measuring both fT4 and TSH was estimated for the population (in 2004 and 2013) and compared with 2 other relevant studies and has become cheaper with time.
Laboratory tests of thyroid function: pitfalls in interpretation
When the clinical suspicion is strong (e.g. in a patient who exhibits overt symptoms and signs of hyperthyroidism), thyroid function tests are helpful in confirming the diagnosis. However, situations
Thyrotropin isoforms: implications for thyrotropin analysis and clinical practice.
This review focuses on the dissociation between the clinical state and serum TSH concentrations and addresses clinically important aspects of TSH analysis.
Unexpected Elevated Free Thyroid Hormones in Pregnancy
A 35-year-old woman with a known diagnosis of chronic autoimmune thyroiditis was referred to the authors' clinic at week 26 of her second pregnancy, and was clinically euthyroid.
The thyroid gland regulates metabolism, therefore thyroid dysfunction has an impact throughout the body In iodine-replete areas, autoimmune disease is the commonest cause of thyroid disorders Thyroid
Management of subclinical hypothyroidism.
Patients with symptoms suggestive of hypothyroidism and those patients with thyroid-stimulating hormone (TSH) levels higher than 10 μIU per mL (10 mIU per L) or positive anti-thyroid peroxidase (TPO) antibodies are treated with levothyroxine.


American Thyroid Association assessment of current free thyroid hormone and thyrotropin measurements and guidelines for future clinical assays. The Committee on Nomenclature of the American Thyroid Association.
The following Special Report from the Committee on Nomenclature of the American Thyroid Association (A TA) is an attempt to clarify some of the confusion that exists on the use and performance of the
Thyroid function testing in psychiatric illness: Usefulness and limitations
  • R. Arem, K. Cusi
  • Medicine, Psychology
    Trends in Endocrinology & Metabolism
  • 1997
Current status and performance goals for serum thyrotropin (TSH) assays.
If manufacturers and laboratories collaborate to solve the sensitivity and specificity problems discussed here, clinical laboratories should be better able to consistently deliver reliable serum TSH measurements across the full range of TSH concentrations encountered in clinical practice.
Dynamics of thyroid hormone suppression of serum thyrotropin: an invited commentary.
  • C. Spencer
  • Medicine, Biology
    European journal of endocrinology
  • 1996
The data showed that both serum TSH and Tg concentrations fell over time with single monoexpontential suppression patterns and were proportional to the thyroxine dose administered, which emphasizes the work of Larsen and others showing that it is local T 3' generated from T 4 within the pituitary by the 5'­ deiodinase enzyme system(s), that mediates thyrox­ ine's negative feedback on pituitsary TSH secretion.
Syndromes of thyrotoxicosis with low radioactive iodine uptake.
  • D. Ross
  • Medicine, Biology
    Endocrinology and metabolism clinics of North America
  • 1998
Thyroid Function Tests in Patients with Familial Dysalbuminaemic Hyperthyroxinaemia (FDH)
Two patients with familial dysalbuminaemic hyperthyroxinaemia (FDH) are described in whom the albumin variant resulted in raised total T4 levels, and artefactually raised free T4 using a
Autoantibodies to thyroxin and triiodothyronine.
It is suggested that measurement of thyrotropin by an assay with improved detection limits will aid in correctly determining thyroid status, and the presence of thyroid hormone antibodies should be suspected when results of thyroid-function tests are discordant with the clinical state.
Sequence analysis of the thyrotropin (TSH) receptor gene in congenital primary hypothyroidism associated with TSH unresponsiveness.
The results indicate that congenital primary hypothyroidism associated with TSH unresponsiveness is unlikely to be due to mutations in the TSHR-structure gene.
Variations in thyroid hormone transport proteins and their clinical implications.
Variations in major thyroid hormone transport proteins may be inherited or acquired and may be associated with changes in serum concentration of the proteins or their affinity for thyroid hormones, but changes in transthyretin and albumin are also observed.