Interpretation of the complexity of innate immune responses by functional genomics

@article{RicciardiCastagnoli2002InterpretationOT,
  title={Interpretation of the complexity of innate immune responses by functional genomics},
  author={Paola Ricciardi-Castagnoli and Francesca Granucci},
  journal={Nature Reviews Immunology},
  year={2002},
  volume={2},
  pages={881-889}
}
Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation… CONTINUE READING

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References

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Showing 1-10 of 71 references

Human macrophage activation programs induced by bacterial pathogens.

Proceedings of the National Academy of Sciences of the United States of America • 2002

Stereotyped and specific gene expression programs in human innate immune responses to bacteria.

Proceedings of the National Academy of Sciences of the United States of America • 2002

Systems biology : a brief overview

T. A. Ince, R. A. Weinberg
Science • 2002

Whole - istic biology

L. Chong, L. B. Ray
Science • 2002

a brief overview

Kitano, H. Systems biology
Science 295, 1662–1664 • 2002

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