Interpretation of subgroup analyses in randomized trials: heterogeneity versus secondary interventions.

@article{VanderWeele2011InterpretationOS,
  title={Interpretation of subgroup analyses in randomized trials: heterogeneity versus secondary interventions.},
  author={Tyler J. VanderWeele and Mirjam J. Knol},
  journal={Annals of internal medicine},
  year={2011},
  volume={154 10},
  pages={680-3}
}
In randomized trials with subgroup analyses, the primary treatment or intervention of interest is randomized, but the secondary factors defining subgroups are not. This article clarifies when confounding is an issue in subgroup analyses. If investigators are interested simply in targeting subpopulations for intervention, control for confounding is not needed. If investigators are interested in intervening on the secondary factors that define the subgroups to increase the treatment effect or in… CONTINUE READING

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