Interpretation of outcomes of antiarrhythmic clinical trials: design features and population impact.

  title={Interpretation of outcomes of antiarrhythmic clinical trials: design features and population impact.},
  author={Robert Jerome Myerburg and Raul David Mitrani and Alberto Interian and Agustin Castellanos},
  volume={97 15},
The results of the Cardiac Arrhythmia Suppression Trials (CAST and CAST II) were a watershed in attitudes about management of cardiac arrhythmias. 1–3 On the basis of the then-prevailing assumption that premature ventricular contractions (PVCs) in the presence of recent myocardial infarction identified a risk for life-threatening arrhythmias and that they also served as the trigger for fatal arrhythmias, it was logical to determine whether suppression of ambient arrhythmias would protect… CONTINUE READING


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