Interpretation of ileal biopsies: morphological features in normal and diseased mucosa

@article{Cuvelier2001InterpretationOI,
  title={Interpretation of ileal biopsies: morphological features in normal and diseased mucosa},
  author={Claude A. Cuvelier and Pieter Demetter and Herman Mielants and Eric M. Veys and Martine De Vos},
  journal={Histopathology},
  year={2001},
  volume={38}
}
One of the advantages of flexible colonoscopy is that the terminal ileum can easily be reached and biopsied by an experienced operator. Thus, the pathologist will, with increasing frequency, receive ileal biopsies from patients who have or may not have ileal disease and it is therefore useful to have a good knowledge of the spectrum of ileal mucosal histology and pathology, of its normal function, and of the changes seen in different conditions. It is also desirable to be aware of diseases that… Expand
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There are doubts about the need of biopsy of this segment in patients with normal ileoscopy and few studies with criteria for macroscopical and microscopical characterization of the ileum were found. Expand
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Ileal intubation is often performed during screening colonoscopies. This had led to the recognition of mild ileitis in many asymptomatic patients. The natural history and clinical significance ofExpand
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The correlation between endoscopic and histological findings was high and the chance of subjects with normal ileoscopy with abdominal pain and/or chronic diarrhea, showing histological alterations was higher in relation to the asymptomatic ones or with other symptoms, although the clinical importance of this datum was not evaluated. Expand
Histological aspects of the terminal ileum: a windows on coeliac disease too?
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  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2006
TLDR
Information concerning the endoscopic features, notably the extent of disease in the colon and the continuity of disease between colon and ileum, together with information about the ileocaecal valve should be imparted to the pathologist, to avoid an erroneous diagnosis of Crohn’s disease. Expand
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There was a significant inverse relationship between the number of villus Iels and increasing age and one should avoid overinterpreting the importance of occasional IELs in ileal biopsy specimens from asymptomatic patients. Expand
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This study confirms the importance of knowledge of the main anatomopathological changes related to ileitis by pathologists and endoscopists, making the best diagnosis and follow-up. Expand
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TLDR
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TLDR
This chapter summarizes the role of the pathologist in the management of patients with CD, starting from a glossary of the terms used in the information exchange between the pathologists radiologist gastroenterologist, and surgeon. Expand
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