Interpretation of genetic test results for hereditary nonpolyposis colorectal cancer: implications for clinical predisposition testing.

@article{Syngal1999InterpretationOG,
  title={Interpretation of genetic test results for hereditary nonpolyposis colorectal cancer: implications for clinical predisposition testing.},
  author={Sapna Syngal and Edward Alan Fox and Chunying Li and Mariangela Dovidio and Clarence Eng and Richard D Kolodner and Judy E Garber},
  journal={JAMA},
  year={1999},
  volume={282 3},
  pages={247-53}
}
CONTEXT Genetic testing for cancer predisposition is evolving from purely research applications to affecting clinical management. OBJECTIVE To determine how often genetic test results for hereditary nonpolyposis colorectal cancer (HNPCC) can be definitively interpreted and used to guide clinical management. DESIGN Case-series study conducted in 1996 to 1998 in which a complete sequence analysis of hMSH2 and hMLH1 coding sequence and flanking intronic regions was performed. Mutations were… CONTINUE READING
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In vitro HEREDITARY NONPOLYPOSIS COLORECTAL CANCER 252 JAMA

  • MC Luce, G Marra, DP Chauhan
  • July 21,
  • 1999

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