Interpretation and estimation of vaccine efficacy under heterogeneity.

@article{Halloran1992InterpretationAE,
  title={Interpretation and estimation of vaccine efficacy under heterogeneity.},
  author={M. Elizabeth Halloran and Michael J. Haber and Ira M. Longini},
  journal={American journal of epidemiology},
  year={1992},
  volume={136 3},
  pages={
          328-43
        }
}
Interpretation and estimation of vaccine efficacy is complicated when the vaccine effect is heterogeneous across vaccinated strata. If a person has a certain susceptibility, or probability of becoming infected conditional on a specified exposure to infection, then one effect of a vaccine would be to reduce that susceptibility, possibly to zero. Vaccine efficacy is a function of the relative susceptibilities in the vaccinated and unvaccinated persons. Under heterogeneity of vaccine effect, a… CONTINUE READING
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