Interplay of replication checkpoints and repair proteins at stalled replication forks.

@article{Branzei2007InterplayOR,
  title={Interplay of replication checkpoints and repair proteins at stalled replication forks.},
  author={Dana Branzei and Marco Foiani},
  journal={DNA repair},
  year={2007},
  volume={6 7},
  pages={994-1003}
}
DNA replication is an essential process that occurs in all growing cells and needs to be tightly regulated in order to preserve genetic integrity. Eukaryotic cells have developed multiple mechanisms to ensure the fidelity of replication and to coordinate the progression of replication forks. Replication is often impeded by DNA damage or replication blocks, and the resulting stalled replication forks are sensed and protected by specialized surveillance mechanisms called checkpoints. The… CONTINUE READING

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