Interplay of proteins and lipids in generating membrane curvature.

  title={Interplay of proteins and lipids in generating membrane curvature.},
  author={Todd R Graham and Michael M. Kozlov},
  journal={Current opinion in cell biology},
  volume={22 4},
The majority of intracellular membranes have strongly bent shapes with radii of curvature ranging from 20 to 50 nm. Many different proteins provide the substantial energy needed to generate and sustain this curvature. One of the most effective mechanisms of curvature creation is based on asymmetry of membrane monolayers. Proteins generate this asymmetry by flipping phospholipid across the membrane, modifying lipid molecules, or embedding their hydrophobic domains into the membrane matrix. We… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 71 extracted citations

Endocytosis Controlled by Monolayer Area Asymmetry

Jan - Hendrik Olbertz Dekan der Mathematisch - Naturwi Fakultät
View 5 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 52 references

Role of C2 domain proteins during synaptic vesicle exocytosis.

Biochemical Society transactions • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…