Interplay of pregnane X receptor with other nuclear receptors on gene regulation.


Human body needs to protect itself from a diverse array of harmful chemicals. These chemicals are also involved in drug metabolism, enzyme induction, and can cause adverse drug-drug interactions. Being a member of nuclear receptors (NRs), pregnane X receptor (PXR) has recently emerged as transcriptional regulators of cytochrome P450 (CYP) and transporters expression so as to against xenobiotics exposure. This review describes some common nuclear receptors, i.e. farnesoid X receptor (FXR), small heterodimer partner (SHP), hepatocyte nuclear factor-4alpha (HNF-4alpha), liver X receptor (LXR), glucocorticoid receptor (GR), constitutive androstane receptor (CAR) that crosstalk with PXR and involvement of coregulators thus control target genes expression.

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@article{Lim2008InterplayOP, title={Interplay of pregnane X receptor with other nuclear receptors on gene regulation.}, author={Yun-Ping Lim and Jin-ding Huang}, journal={Drug metabolism and pharmacokinetics}, year={2008}, volume={23 1}, pages={14-21} }