Interplay of permanent charge and hydrophobicity in the electrospray ionization of glycans.

@article{Walker2010InterplayOP,
  title={Interplay of permanent charge and hydrophobicity in the electrospray ionization of glycans.},
  author={S Hunter Walker and Brian N. Papas and Daniel L. Comins and David C Muddiman},
  journal={Analytical chemistry},
  year={2010},
  volume={82 15},
  pages={
          6636-42
        }
}
The analysis of N-linked glycans by mass spectrometry (MS) has been characterized by low signal-to-noise ratios and high limits of detection due to their hydrophilicity and lack of basic sites able to be protonated. As a result, every step in glycan sample preparation must be thoroughly optimized in order to minimize sample loss, contamination, and analytical variability. Importantly, properties of glycans and their derivatized counterparts must be thoroughly studied in order to exploit certain… CONTINUE READING

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