Interplay of packing and flip-flop in local bilayer deformation. How phosphatidylglycerol could rescue mitochondrial function in a cardiolipin-deficient yeast mutant.

@article{Khalifat2014InterplayOP,
  title={Interplay of packing and flip-flop in local bilayer deformation. How phosphatidylglycerol could rescue mitochondrial function in a cardiolipin-deficient yeast mutant.},
  author={Nada Khalifat and Mohammad Rahimi and Anne-Florence Bitbol and Michel Seigneuret and Jean-Baptiste Fournier and Nicolas Puff and Marino Arroyo and M. Angelova},
  journal={Biophysical journal},
  year={2014},
  volume={107 4},
  pages={
          879-90
        }
}

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References

SHOWING 1-10 OF 62 REFERENCES

Membrane deformation under local pH gradient: mimicking mitochondrial cristae dynamics.

TLDR
The results support the hypothesis of localized bioenergetic transduction and contribute to showing the inherent capacity of cristae morphology to become self-maintaining and to optimize the ATP synthesis.

ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes.

  • M. SeigneuretP. Devaux
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1984
TLDR
It is suggested that an ATP-driven transport of aminoospholipids toward the inner leaflet could be the major cause of the phospholipid asymmetry in the erythrocyte membrane.

Vesicle budding induced by a pore-forming peptide.

We describe, in a system whose uniqueness is that the presence of pores allows the volume to vary as budding proceeds, how phase separation on the surface of spheres extrudes material in the process

On the mechanism of transbilayer transport of phosphatidylglycerol in response to transmembrane pH gradients.

TLDR
It is shown that acyl chain saturation, chain length, and the presence of cholesterol modulate the rate constants for PG transport in a manner similar to that observed for small nonelectrolytes.
...