Interplay of nitric oxide and histamine in the regulation of coronary reactive hyperemia and coronary autoregulation.

Abstract

Reactive hyperemia following 30 s of coronary occlusion in the isolated guinea pig heart is accompanied by a two-fold increase of nitric oxide (NO) and histamine release, which are significantly reduced in the presence of L-NAME, cimetidine and thioperamide, respectively. Great changes of histamine release occur during autoregulation. However, histamine… (More)

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