Interplay of ionic and structural heterogeneity on functional action potential duration gradients: Implications for arrhythmogenesis.

@article{Sampson2002InterplayOI,
  title={Interplay of ionic and structural heterogeneity on functional action potential duration gradients: Implications for arrhythmogenesis.},
  author={Kevin J. Sampson and Craig S. Henriquez},
  journal={Chaos},
  year={2002},
  volume={12 3},
  pages={819-828}
}
Action potential duration (APD) dispersion in the heart is governed by the underlying cellular architecture and the spatial distribution of the membrane properties. Understanding the contribution of each factor is important in designing more effective methods for the control of arrhythmias. Recent experimental studies have shown that the insertion of structural barriers in ionically heterogeneous tissue facilitates the formation of unidirectional block and discordant alternans. In this work… CONTINUE READING
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