Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity.

@article{Wang2010InterplayOH,
  title={Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity.},
  author={Hua Wang and Ogyi Park and Fouad Lafdil and Kezhen Shen and Norio Horiguchi and Shi Yin and Xin-yuan Fu and George Kunos and Bin Gao},
  journal={Hepatology},
  year={2010},
  volume={51 4},
  pages={
          1354-62
        }
}
UNLABELLED Liver regeneration triggered by two-thirds partial hepatectomy is accompanied by elevated hepatic levels of endotoxin, which contributes to the regenerative process, but liver inflammation and apoptosis remain paradoxically limited. Here, we show that signal transducer and activator of transcription 3 (STAT3), an important anti-inflammatory signal, is activated in myeloid cells after partial hepatectomy and its conditional deletion results in an enhanced inflammatory response… CONTINUE READING
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