Interplay of estrogen receptors and GPR30 for the regulation of early membrane initiated transcriptional effects: A pharmacological approach.

@article{Notas2012InterplayOE,
  title={Interplay of estrogen receptors and GPR30 for the regulation of early membrane initiated transcriptional effects: A pharmacological approach.},
  author={Georgios Notas and Marilena Kampa and Vassiliki Pelekanou and Elias Castanas},
  journal={Steroids},
  year={2012},
  volume={77 10},
  pages={943-50}
}
Estrogens exert their effect through ERα and ERβ intracellular transcription factors and rapid, usually membrane-initiated receptors, influencing cytosolic signaling and transcription. The nature of extranuclear estrogen elements has not been elucidated so far; classical or alternatively transcribed ER isoforms (ERα36, ERα46) anchored to the plasma membrane and GPR30 (GPER1) have been reported to exert early estrogen actions. Here, we used E2-BSA, an impermeable estradiol analog for a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 91 references

G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha G

  • A Vivacqua, R Lappano, P De Marco, D Sisci, S Aquila, F De Amicis
  • Notas et al. / Steroids
  • 2012
Highly Influential
6 Excerpts

ERalpha17p, an ERalpha P(295)–T(311) fragment, modifies the migration of breast cancer cells, through actin cytoskeleton rearrangements

  • M Kampa, V Pelekanou, D Gallo, G Notas, M Troullinaki, I Pediaditakis
  • J Cell Biochem 2011;112:3786–96
  • 2011
1 Excerpt

Similar Papers

Loading similar papers…