Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence.

@article{Ferreon2009InterplayOA,
  title={Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence.},
  author={Allan Chris M Ferreon and Yann Gambin and Edward A Lemke and Ashok A Deniz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 14},
  pages={5645-50}
}
We studied the coupled binding and folding of alpha-synuclein, an intrinsically disordered protein linked with Parkinson's disease. Using single-molecule fluorescence resonance energy transfer and correlation methods, we directly probed protein membrane association, structural distributions, and dynamics. Results revealed an intricate energy landscape on which binding of alpha-synuclein to amphiphilic small molecules or membrane-like partners modulates conformational transitions between a… CONTINUE READING

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