Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements.

  title={Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements.},
  author={Priscilla Turelli and Nathaly Castro-D{\'i}az and Flavia Marzetta and A. Kapopoulou and Charl{\`e}ne Raclot and Julien Duc and Vannary Tieng and Simon Quenneville and Didier Trono},
  journal={Genome research},
  volume={24 8},
Reverse transcription-derived sequences account for at least half of the human genome. Although these retroelements are formidable motors of evolution, they can occasionally cause disease, and accordingly are inactivated during early embryogenesis through epigenetic mechanisms. In the mouse, at least for endogenous retroviruses, important mediators of this process are the tetrapod-specific KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofactor TRIM28. The present study demonstrates… CONTINUE READING
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